FDA Approved Antidepressants

Medication Classes, Indications, Contraindications, Side Effects, Warnings, and Dosages

Last updated 10/01/14

Antidepressant Basics

List of All FDA Approved Antidepressant Medications

Definition: Antidepressants are pharmaceutical compounds that improve mood and relieve the symptoms of depression, and have numerous indications including unipolar major depression, generalized anxiety disorder, panic disorder, social anxiety disorder, seasonal affective disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and smoking cessation. Common side effects of antidepressants may affect the following bodily systems: cardiovascular, dermatological, endocrine, gastrointestinal, neurological, immune, musculoskeletal, ophthalmic, psychiatric, reproductive, hematologic, renal, and hepatic. This page contains a list of all antidepressants approved for use in the USA by the FDA.

Click on the underlined medications for more information.

Selective serotonin reuptake inhibitors (SSRIs)

Celexa (Citalopram)
Lexapro (Escitalopram)
Prozac (Fluoxetine)
Luvox (Fluvoxamine)
Paxil (Paroxetine)
Zoloft (Sertraline)

Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Serotonin Modulators

Serzone (Nfazodone)
Desyrel (Trazodone)
Viibryd (Vilazodone)

Atypical antidepressants

Wellbutrin (Bupropion)
Remeron (Mirtazapine)
Brintellix (Vortioxetine)
Valdoxan (Agomelatine – unavailable in the USA)

Tricyclic antidepressants (TCAs)

Elavil (Amitriptyline)
Anafranil (Clomipramine)
Sinequan (Doxepin)
Asendin (Amoxapine)
Tofranil (Imipramine)
Surmontil (Trimipramine)
Norpramine (Desipramine)
Pamelor (Nortriptyline)
Vivactil (Protriptyline)
Ludiomil (Maprotiline)

Monoamine oxidase inhibitors (MAOIs)

Parnate (Tranylcypromine)
Nardil (Phenelzine)
Emsam (Selegiline transdermal)
Marplan (Isocarboxazid)

FDA Approved and Off-label Uses of Common Antidepressants

This table applies to adults only

The table does not provide a comprehensive list of all uses

Major Depressive Disorder Generalized Anxiety Disorder Panic Disorder Social Anxiety Disorder Seasonal Affective Disorder Smoking Sessation Post-traumatic Stress Disorder (PTSD) Obsessive-Compulsive Disorder
Depression Health Network does not recommended or endorse the off-label uses of medications.
Celexa Approved Off-label Off-label Off-label
Cymbalta Approved Approved Off-label
Desipramine Approved Off-label
Effexor XR Approved Approved Approved Approved
Lexapro Approved Approved Off-label Off-label
Luvox Off-label Off-label Approved
Pamelor Approved Off-label Off-label
Parnate Approved Off-label Off-label Off-label
Paxil Approved Approved Approved Approved Approved Approved
Prozac Approved Approved Approved
Remeron Approved Off-label
Wellbutrin Approved Approved Approved
Zoloft Approved Approved Approved Approved Approved